CO-FUNDED PROJECT BY IVADO
The human body is made up of trillions of cells that come in all shapes and sizes. The instructions to generate this staggering cellular diversity is encoded in our DNA genome, which serves as a template to synthesize thousands of RNA molecules that serve as the template for protein synthesis. Unlike our genomic DNA, which resides in the cells nucleus, RNA molecules are transported outside the nucleus throughout the cell interior to different organelles where they are locally utilized. This process of RNA localization is carried out via an intricate subcellular transit system, analogous to the roads of a large city. Our project aimed to utilize machine learning approaches to help understand the molecular logic of how this transport system works, in particular the molecular vehicles and addressing signals that dictate this transport. We developed several tools and insights that will help better understand RNA transport processes and evaluate how these may go awry in diseases in which this transport is perturbed.
Lead Genome Centre: Génome Québec
Partner: IVADO
Co-investigators:
| Mathieu | Blanchette | Université McGill |
| Jérôme | Waldispühl | Université McGill |