{"id":30131,"date":"2025-02-28T09:00:00","date_gmt":"2025-02-28T14:00:00","guid":{"rendered":"https:\/\/genomequebec.wp.vortexdev.com\/?post_type=financed-project&#038;p=30131"},"modified":"2025-03-21T10:49:26","modified_gmt":"2025-03-21T14:49:26","slug":"integration-of-the-polygenic-risk-score-in-the-management-of-women-at-moderate-genetic-or-familial-risk-of-breast-cancer","status":"publish","type":"financed-project","link":"https:\/\/genomequebec.wp.vortexdev.com\/en\/funded-projects\/integration-of-the-polygenic-risk-score-in-the-management-of-women-at-moderate-genetic-or-familial-risk-of-breast-cancer\/","title":{"rendered":"Integration of the polygenic risk score in the management of women at moderate genetic or familial risk of breast cancer"},"content":{"rendered":"\n<p><strong>A project co-financed with the Quebec Breast Cancer Foundation<\/strong><\/p>\n\n\n\n<p><strong>User<\/strong>: OPTILAB \u2013 Capitale Nationale and Illumina Canada<\/p>\n\n\n\n<p>Breast cancer is the most common cancer among women in Quebec and the second leading cause of cancer-related mortality. A biennial mammography screening is offered to all women aged 50 to 74. However, for women at higher risk due to family history or hereditary genetic predisposition, earlier or more intensive monitoring, or even preventive surgery, may be considered.<\/p>\n\n\n\n<p>Integrating genomic data, such as the polygenic risk score, in addition to other risk factors, would allow for a better assessment of the cancer risk in these women, nearly half of whom are at increased risk. This would offer a more personalized approach, tailored to their actual breast cancer risk. Women at high risk would receive enhanced monitoring, enabling earlier cancer detection, improving their prognosis and quality of life, while avoiding unnecessary screening for those at low risk.<\/p>\n\n\n\n<p>To this end, we will validate a genetic analysis of the risk score at the CHU de Qu\u00e9bec laboratory and integrate it into the oncogenetics clinic. Ultimately, this approach will be implemented within the healthcare system in Quebec.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">In the media <\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.journaldelevis.com\/jdl\/25\/Sant%C3%A9.html?id=41960\" target=\"_blank\" rel=\"noreferrer noopener\">Une nouvelle solution pour d\u00e9tecter le cancer du sein<\/a><\/li>\n<\/ul>\n","protected":false},"featured_media":0,"template":"","class_list":["post-30131","financed-project","type-financed-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/genomequebec.wp.vortexdev.com\/en\/wp-json\/wp\/v2\/financed-project\/30131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomequebec.wp.vortexdev.com\/en\/wp-json\/wp\/v2\/financed-project"}],"about":[{"href":"https:\/\/genomequebec.wp.vortexdev.com\/en\/wp-json\/wp\/v2\/types\/financed-project"}],"wp:attachment":[{"href":"https:\/\/genomequebec.wp.vortexdev.com\/en\/wp-json\/wp\/v2\/media?parent=30131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}